Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations in the hematopoietic stem or progenitor cells (HSPCs) leading to the expansion of blasts in the hematopoietic system. The heterogeneity and evolution of cance...

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Bibliographic Details
Main Authors: Yanan Zhai, Prashant Singh, Anna Dolnik, Peter Brazda, Nader Atlasy, Nunzio del Gaudio, Konstanze Döhner, Hartmut Döhner, Saverio Minucci, Joost Martens, Lucia Altucci, Wout Megchelenbrink, Lars Bullinger, Hendrik G. Stunnenberg
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Molecular Cancer
Subjects:
Acute myeloid Leukemia
Single-cell RNA sequencing
Recurrence
Leukemic stem cells
Genome analysis
Online Access:https://doi.org/10.1186/s12943-022-01635-4

Internet

https://doi.org/10.1186/s12943-022-01635-4

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