Autism-Risk Gene necab2 Regulates Psychomotor and Social Behavior as a Neuronal Modulator of mGluR1 Signaling

Autism-Risk Gene necab2 Regulates Psychomotor and Social Behavior as a Neuronal Modulator of mGluR1 Signaling

BackgroundDe novo deletion of the neuronal calcium-binding protein 2 (NECAB2) locus is associated with idiopathic autism spectrum disorders (ASDs). The in vivo function of NECAB2 in the brain remains largely elusive.MethodsWe investigated the morphological and behavioral profiles of both necab2 knoc...

Full description

Bibliographic Details
Main Authors: Zexu Chen, Han Long, Jianhua Guo, Yiran Wang, Kezhe He, Chenchen Tao, Xiong Li, Keji Jiang, Su Guo, Yan Pi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorders
calcium-binding protein
social behavior
metabotropic glutamate receptor 1
cerebellum
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.901682/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.901682/full

Similar Items