Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice

Abstract The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role in controlling learning, memory and synaptic plasticity. Since early-life inflammation has been reported to adversel...

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Bibliographic Details
Main Authors: Jing Rong, Yang Yang, Min Liang, Haiquan Zhong, Yingchun Li, Yichao Zhu, Sha Sha, Lei Chen, Rong Zhou
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Neuroinflammation
Subjects:
Neonatal inflammation
Memory
GABAergic synaptic transmission
Cytokines
Methylation
Online Access:https://doi.org/10.1186/s12974-023-02697-x

Internet

https://doi.org/10.1186/s12974-023-02697-x

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