Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated in several major brain diseases including Huntington’...

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Bibliographic Details
Main Authors: Korrapati V. Sathyasaikumar, Verónica Pérez de la Cruz, Benjamín Pineda, Gustavo Ignacio Vázquez Cervantes, Daniela Ramírez Ortega, David W. Donley, Paul L. Severson, Brian L. West, Flaviano Giorgini, Jonathan H. Fox, Robert Schwarcz
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
astrocyte
Huntington’s disease
kynurenine pathway
microglia
schizophrenia
Online Access:https://www.mdpi.com/2076-3921/11/2/315

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https://www.mdpi.com/2076-3921/11/2/315

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