Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated in several major brain diseases including Huntington’...

Full description

Bibliographic Details
Main Authors:	Korrapati V. Sathyasaikumar, Verónica Pérez de la Cruz, Benjamín Pineda, Gustavo Ignacio Vázquez Cervantes, Daniela Ramírez Ortega, David W. Donley, Paul L. Severson, Brian L. West, Flaviano Giorgini, Jonathan H. Fox, Robert Schwarcz
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Antioxidants
Subjects:	astrocyte Huntington’s disease kynurenine pathway microglia schizophrenia
Online Access:	https://www.mdpi.com/2076-3921/11/2/315

Similar Items

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane
by: Aisha M. Swaih, et al.
Published: (2022-09-01)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
by: Robert S. Phillips, et al.
Published: (2019-02-01)

Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas
by: Gustavo Ignacio Vázquez Cervantes, et al.
Published: (2021-08-01)

Kynurenine 3-monooxygenase: an influential mediator of neuropathology
by: Jennifer M Parrott, et al.
Published: (2015-08-01)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
by: Tamera D. Hughes, et al.
Published: (2022-01-01)

Clinical predictors of kynurenine pathway aberrations in schizophrenia and bipolar disorder
by: K. Skorobogatov, et al.
Published: (2022-06-01)

The kynurenine pathway of tryptophan catabolism and schizophrenia
by: Marković Miloš, et al.
Published: (2023-01-01)

Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation
by: Randi Lassiter, et al.
Published: (2021-07-01)

Kynurenine pathway metabolites are associated with gray matter volume in subjects with schizophrenia
by: Sumiao Zhou, et al.
Published: (2022-08-01)

Tryptophan Challenge in Healthy Controls and People with Schizophrenia: Acute Effects on Plasma Levels of Kynurenine, Kynurenic Acid and 5-Hydroxyindoleacetic Acid
by: Korrapati V. Sathyasaikumar, et al.
Published: (2022-08-01)

Kynurenine acid - metabolism and regulation of kynurenine pathway
by: Piotr Kozłowski, et al.
Published: (2017-07-01)

Kynurenine acid - metabolism and regulation of kynurenine pathway
by: Piotr Kozłowski, et al.
Published: (2017-07-01)

IDO and Kynurenine Metabolites in Peripheral and CNS Disorders
by: Yi-Shu Huang, et al.
Published: (2020-03-01)

Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer
by: Chun-Yu Liu, et al.
Published: (2021-04-01)

Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia
by: Qingyan Yang, et al.
Published: (2022-10-01)

Associations Between the Kynurenine Pathway, Proinflammatory Cytokines, and Brain-Derived Neurotrophic Factor in Hospitalized Patients With Chronic Schizophrenia: A Preliminary Study
by: Naomichi Okamoto, et al.
Published: (2021-07-01)

The role of kynurenine and kynurenine metabolites in psoriasis
by: Akyurek Fikret, et al.
Published: (2024-12-01)

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review
by: Bruno Pedraz-Petrozzi, et al.
Published: (2020-02-01)

Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia
by: Erika Sugisawa, et al.
Published: (2022-03-01)

Tracking TRYCAT: A Critical Appraisal of Kynurenine Pathway Quantifications in Blood
by: Violette Coppens, et al.
Published: (2022-02-01)

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
by: Mustafa N. Mithaiwala, et al.
Published: (2021-06-01)

Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia
by: Mian Li, et al.
Published: (2025-01-01)

Dynamic Changes in Metabolites of the Kynurenine Pathway in Alzheimer’s Disease, and Huntington’s Disease: A Systematic Review of Pre-clinical Studies
by: Farzaneh Ahmadi, et al.
Published: (2024-01-01)

Kynurenine Pathway in Psoriasis—a Promising Link?
by: A. Stepaniuk, et al.
Published: (2023-06-01)

Pathological characterization of T2*-weighted MRI contrast in the striatum of Huntington’s disease patients
by: Marjolein Bulk, et al.
Published: (2020-01-01)

Phytochemical treatments target kynurenine pathway induced oxidative stress
by: K. Parasram
Published: (2018-01-01)

Decreased Plasma Levels of Kynurenine and Kynurenic Acid in Previously Treated and First-Episode Antipsychotic-Naive Schizophrenia Patients
by: Miloš Marković, et al.
Published: (2023-12-01)

On the Antioxidant Properties of L-Kynurenine: An Efficient ROS Scavenger and Enhancer of Rat Brain Antioxidant Defense
by: Daniela Ramírez Ortega, et al.
Published: (2021-12-01)

Relationship between metabolites of peripheral tryptophan-kynurenine metabolic pathway and clinical symptoms in patients with schizophrenia
by: Wu Yue, et al.
Published: (2024-02-01)

Dynamic changes in metabolites of the kynurenine pathway in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease: A systematic Review and meta-analysis
by: Mobina Fathi, et al.
Published: (2022-10-01)

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
by: Paolo Guidetti, et al.
Published: (2006-07-01)

IDO/kynurenine pathway in cancer: possible therapeutic approaches
by: Eslam E. Abd El-Fattah
Published: (2022-08-01)

The Kynurenine 3-Monooxygenase Encoding Gene, BcKMO, Is Involved in the Growth, Development, and Pathogenicity of Botrytis cinerea
by: Kang Zhang, et al.
Published: (2018-05-01)

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
by: Gábor Nagy-Grócz, et al.
Published: (2017-06-01)

Corrigendum: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
by: Gábor Nagy-Grócz, et al.
Published: (2020-09-01)

Linking major depressive disorder pathogenesis with kynurenine pathway - a literature review
by: Dominik Szawica, et al.
Published: (2023-03-01)

Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders
by: Adrian Mor, et al.
Published: (2024-07-01)

Analyzing the Potential Biological Determinants of Autism Spectrum Disorder: From Neuroinflammation to the Kynurenine Pathway
by: Rosa Savino, et al.
Published: (2020-09-01)

Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects
by: Bradley D. Pearce, et al.
Published: (2020-11-01)

Kynurenines as a Novel Target for the Treatment of Malignancies
by: Adrian Mor, et al.
Published: (2021-06-01)