Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist

Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist

Abstract The novel oral complement factor 5a receptor 1 antagonist ACT‐1014‐6470 was well tolerated in single‐ and multiple‐ascending dose studies, including 24 h Holter electrocardiogram (ECG) recordings evaluating its cardiodynamics based on data from single doses of 30–200 mg and twice‐daily (b.i...

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Bibliographic Details
Main Authors: Marion Anliker‐Ort, Chih‐hsuan Hsin, Andreas Krause, Marc Pfister, John van denAnker, Jasper Dingemanse, Priska Kaufmann
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Pharmacology Research & Perspectives
Subjects:
C5a1 receptor antagonist
cardiac safety
complement system
concentration‐QT modeling
Holter ECG monitoring
Online Access:https://doi.org/10.1002/prp2.1112

Internet

https://doi.org/10.1002/prp2.1112

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