Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans

Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans

Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used the nematode Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin. In this study, we used C. elegans to explore cisplatin effect...

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Bibliographic Details
Main Authors: Carmen Martínez-Fernández, Milana Bergamino, Alfonso Schiavi, David Brena, Natascia Ventura, Sebastian Honnen, Alberto Villanueva, Ernest Nadal, Julián Cerón
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Disease Models & Mechanisms
Subjects:
c. elegans
crispr-cas9
cisplatin
glucose
mitochondria
neurotoxicity
Online Access:http://dmm.biologists.org/content/15/3/dmm049161

Internet

http://dmm.biologists.org/content/15/3/dmm049161

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