SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression

SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression

Abstract Background Spalt-like protein 4 (SALL4) is a stemness-related transcription factor whose abnormal re-expression contributes to cancer initiation and progression. However, the role of SALL4 in cancer angiogenesis remains unknown. Methods Analyses of clinical specimens via TCGA datasets were...

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Bibliographic Details
Main Authors: Fatma A. Abouelnazar, Xiaoxin Zhang, Jiahui Zhang, Maoye Wang, Dan Yu, Xueyan Zang, Jiayin Zhang, Yixin Li, Jing Xu, Qiurong Yang, Yue Zhou, Haozhou Tang, Yanzheng Wang, Jianmei Gu, Xu Zhang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cancer Cell International
Subjects:
Gastric cancer
Angiogenesis
SALL4
VEGF
CRISPR/Cas9
Thalidomide
Online Access:https://doi.org/10.1186/s12935-023-02985-9

Internet

https://doi.org/10.1186/s12935-023-02985-9

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