Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancer

Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancer

Abstract Background The cellular tumor protein p53 (TP53) is a tumor suppressor gene that is frequently mutated in human cancers. Among various cancer types, the very aggressive high‐grade serous ovarian carcinoma (HGSOC) exhibits the highest prevalence of TP53 mutations, present in >96% of cases...

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Bibliographic Details
Main Authors: Monika Raab, Izabela Kostova, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Seyed Mohsen Aberoumandi, Evelyn Ullrich, Sven Becker, Mourad Sanhaji, Klaus Strebhardt
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Cancer Communications
Subjects:
apoptosis
cell cycle
chromosomal instability
HGSOC metastatic intraperitoneal mouse model
HGSOC orthotopic Xenograft model
high‐grade serous ovarian cancer
Online Access:https://doi.org/10.1002/cac2.12511

Internet

https://doi.org/10.1002/cac2.12511

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