FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress

FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress

Abstract In this study, we report a novel function of FCN3 (Ficolin 3), a secreted lectin capable of activating the complement pathway, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of FCN3 was strongly down-regulated in cancer tissues compared to matched normal lung tis...

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Bibliographic Details
Main Authors: Haeyeon Jang, Yukyung Jun, Suyeon Kim, Eunjeong Kim, Yeonjoo Jung, Byung Jo Park, Jinseon Lee, Jhingook Kim, Sanghyuk Lee, Jaesang Kim
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03675-y

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https://doi.org/10.1038/s41419-021-03675-y

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