Inactivation of the UL37 Deamidase Enhances Virus Replication and Spread of the HSV-1(VC2) Oncolytic Vaccine Strain and Secretion of GM-CSF

Inactivation of the UL37 Deamidase Enhances Virus Replication and Spread of the HSV-1(VC2) Oncolytic Vaccine Strain and Secretion of GM-CSF

The HSV-1 (VC2) live-attenuated vaccine strain was engineered with specific deletions in the amino termini of glycoprotein K (gK) and membrane protein UL20, rendering the virus unable to enter neurons and establish latency. VC2 replicates efficiently in epithelial cell culture but produces lower vir...

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Bibliographic Details
Main Authors: Carolyn M. Clark, Nithya Jambunathan, Therese M. A. Collantes, Konstantin G. Kousoulas
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
herpesvirus
VC2
UL37
GM-CSF
glycoprotein K
UL20
Online Access:https://www.mdpi.com/1999-4915/15/2/367

Internet

https://www.mdpi.com/1999-4915/15/2/367

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