Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals

Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals

Inverted repeat (IR) DNA sequences compose cruciform structures. Some genetic disorders are the result of genome inversion or translocation by cruciform DNA structures. The present study examined whether exogenous DNA integration into the chromosomes of transgenic animals was related to cruciform DN...

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Bibliographic Details
Main Authors: Huan Ou-Yang, Shiao-Hsuan Yang, Wei Chen, Shang-Hsun Yang, Abdulkadir Cidem, Li-Ying Sung, Chuan-Mu Chen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
inverted repeat (IR)
cruciform
transgene
double-strand break (DSB)
DNA repair
homologous recombination (HR)
Online Access:https://www.mdpi.com/1422-0067/23/7/3973

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https://www.mdpi.com/1422-0067/23/7/3973

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