Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry
ObjectiveTo develop a method for the determination of nosiheptide residue in food animal tissues （porcine muscle， porcine liver， porcine kidney， chicken muscle， chicken liver and chicken kidney） with high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS）.MethodsAfter extracted...
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| Format: | Article |
| Language: | zho |
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The Editorial Office of Chinese Journal of Food Hygiene
2022-07-01
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| Series: | Zhongguo shipin weisheng zazhi |
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| Online Access: | http://www.zgspws.com/zgspwszz/article/abstract/202204019?st=article_issue |
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| author | NIE Chen HAN Jingjing ZHAO Sa YANG Fan HE Jingcheng WANG Peifeng LI Mingzhe LIN Chao ZHANG Hongwei |
| author_facet | NIE Chen HAN Jingjing ZHAO Sa YANG Fan HE Jingcheng WANG Peifeng LI Mingzhe LIN Chao ZHANG Hongwei |
| author_sort | NIE Chen |
| collection | DOAJ |
| description | ObjectiveTo develop a method for the determination of nosiheptide residue in food animal tissues （porcine muscle， porcine liver， porcine kidney， chicken muscle， chicken liver and chicken kidney） with high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS）.MethodsAfter extracted by 0.1% acidic acetonitrile， the nosiheptide extract was cleaned up by Captiva ND cartridge and determined by HPLC-MS/MS in negative electrospray ionization mode. Quantification was performed using corresponding matrix-matched calibration curves.ResultsNosiheptide in corresponding matrix showed good linear relationships （r>0.99） in the calibration range of 2~200 μg/L， and the limit of detection （LOD） and limit of quantification （LOQ） of the method were 2.0 and 7.0 μg/kg， respectively. The recoveries of the method ranged from 76.27% to 92.31% at the spiking level of 3.5， 7.0 and 70 μg/kg with relative standard deviations of 2.15%~8.03%.ConclusionThe proposed method is simple， rapid， accurate as well as reproducible and can be applied to monitor and determine nosiheptide residue in food animal tissues. |
| first_indexed | 2024-04-11T04:47:04Z |
| format | Article |
| id | doaj.art-cdd76db37636453db2489e8cc0b762a0 |
| institution | Directory Open Access Journal |
| issn | 1004-8456 |
| language | zho |
| last_indexed | 2024-04-11T04:47:04Z |
| publishDate | 2022-07-01 |
| publisher | The Editorial Office of Chinese Journal of Food Hygiene |
| record_format | Article |
| series | Zhongguo shipin weisheng zazhi |
| spelling | doaj.art-cdd76db37636453db2489e8cc0b762a02022-12-27T09:24:57ZzhoThe Editorial Office of Chinese Journal of Food HygieneZhongguo shipin weisheng zazhi1004-84562022-07-0134475576010.13590/j.cjfh.2022.04.0191004-8456（2022）04-0755-06Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometryNIE Chen0HAN Jingjing1ZHAO Sa2YANG Fan3HE Jingcheng4WANG Peifeng5LI Mingzhe6LIN Chao7ZHANG Hongwei8Qingdao Customs Technology Center, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaSchool of Food Science and Engineering, Ocean University of China, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaQingdao Customs Technology Center, Shandong Qingdao 266002, ChinaObjectiveTo develop a method for the determination of nosiheptide residue in food animal tissues （porcine muscle， porcine liver， porcine kidney， chicken muscle， chicken liver and chicken kidney） with high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS）.MethodsAfter extracted by 0.1% acidic acetonitrile， the nosiheptide extract was cleaned up by Captiva ND cartridge and determined by HPLC-MS/MS in negative electrospray ionization mode. Quantification was performed using corresponding matrix-matched calibration curves.ResultsNosiheptide in corresponding matrix showed good linear relationships （r>0.99） in the calibration range of 2~200 μg/L， and the limit of detection （LOD） and limit of quantification （LOQ） of the method were 2.0 and 7.0 μg/kg， respectively. The recoveries of the method ranged from 76.27% to 92.31% at the spiking level of 3.5， 7.0 and 70 μg/kg with relative standard deviations of 2.15%~8.03%.ConclusionThe proposed method is simple， rapid， accurate as well as reproducible and can be applied to monitor and determine nosiheptide residue in food animal tissues.http://www.zgspws.com/zgspwszz/article/abstract/202204019?st=article_issuehigh performance liquid chromatography-tandem mass spectrometrynosiheptidefood animal tissues |
| spellingShingle | NIE Chen HAN Jingjing ZHAO Sa YANG Fan HE Jingcheng WANG Peifeng LI Mingzhe LIN Chao ZHANG Hongwei Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry Zhongguo shipin weisheng zazhi high performance liquid chromatography-tandem mass spectrometry nosiheptide food animal tissues |
| title | Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry |
| title_full | Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry |
| title_fullStr | Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry |
| title_full_unstemmed | Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry |
| title_short | Determination of nosiheptide residue in food animal tissues by high performance liquid chromatography-tandem mass spectrometry |
| title_sort | determination of nosiheptide residue in food animal tissues by high performance liquid chromatography tandem mass spectrometry |
| topic | high performance liquid chromatography-tandem mass spectrometry nosiheptide food animal tissues |
| url | http://www.zgspws.com/zgspwszz/article/abstract/202204019?st=article_issue |
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