Functional Dissection of the Epidermal Growth Factor Receptor Epitopes Targeted by Panitumumab and Cetuximab

Functional Dissection of the Epidermal Growth Factor Receptor Epitopes Targeted by Panitumumab and Cetuximab

Cetuximab and panitumumab, two antibodies targeting the extracellular domain of the epidermal growth factor receptor (EGFR), are of major clinical importance particularly in the treatment of metastatic colorectal cancer. As patients may acquire resistance-mediating mutations within the extracellular...

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Bibliographic Details
Main Authors: Mareike Voigt, Friederike Braig, Markus Göthel, Alexander Schulte, Katrin Lamszus, Carsten Bokemeyer, Mascha Binder
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861280114X

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http://www.sciencedirect.com/science/article/pii/S147655861280114X

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