A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 activation

A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 activation

Sepsis is a significant cause of mortality in critically ill patients. Acute lung injury (ALI) is a leading cause of death in these patients. Endothelial cells exposed to the bacterial endotoxin lipopolysaccharide (LPS) can progress into pyroptosis, a programmed lysis of cell death triggered by infl...

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Bibliographic Details
Main Authors: Rui Yang, Xiaojuan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
acute lung injury
pyroptosis
endothelial cells
high mobility group 1
caspase-11
heparin
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.984835/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.984835/full

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