Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status

Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status

The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an important regulator of dormant intestinal stem cells (d-I...

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Bibliographic Details
Main Authors: Camilla A. Richmond, Manasvi S. Shah, Luke T. Deary, Danny C. Trotier, Horatio Thomas, Dana M. Ambruzs, Lijie Jiang, Bristol B. Whiles, Hannah D. Rickner, Robert K. Montgomery, Alessio Tovaglieri, Diana L. Carlone, David T. Breault
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
dormant
quiescent
intestinal stem cells
PTEN
fasting
MTORC1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715013509

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http://www.sciencedirect.com/science/article/pii/S2211124715013509

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