Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis

Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis

Ulcerative colitis (UC) is characterized by widespread relapsing inflammation of the colonic mucosa. Colitis-associated cancer (CAC) is one of the most serious complications of a prolonged history of UC. Hydrogen sulfide (H2S) has emerged as an important physiological mediator of gastrointestinal ho...

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Bibliographic Details
Main Authors: Ketan K. Thanki, Paul Johnson, Edward J. Higgins, Manjit Maskey, Ches’Nique Phillips, Swetaleena Dash, Francisco Arroyo Almenas, Armita Abdollahi Govar, Bing Tian, Romain Villéger, Ellen Beswick, Rui Wang, Csaba Szabo, Celia Chao, Irina V. Pinchuk, Mark R. Hellmich, Katalin Módis
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
Inflammatory bowel disease
Colorectal cancer
Hydrogen sulfide
Transsulfuration pathway
Ulcerative colitis
Bone marrow
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001896

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http://www.sciencedirect.com/science/article/pii/S2213231722001896

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