Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in <i>E</i>. <i>coli</i> Strains

Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in <i>E</i>. <i>coli</i> Strains

An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields. Further, using the developed cyclisation reaction, the obtained pepti...

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Bibliographic Details
Main Authors: Parul Sahrawat, Paweł Kowalczyk, Dominik Koszelewski, Mateusz Szymczak, Karol Kramkowski, Aleksandra Wypych, Ryszard Ostaszewski
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
cyclic peptide
ugi multicomponent reaction
diketopiperazines
antimicrobial activity
minimal inhibitory concentration
Online Access:https://www.mdpi.com/1420-3049/27/11/3633

Internet

https://www.mdpi.com/1420-3049/27/11/3633

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