Antithrombin III Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Excessive Autophagy in a Phosphoinositide 3-Kinase/Akt-Dependent Manner

Antithrombin III Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Excessive Autophagy in a Phosphoinositide 3-Kinase/Akt-Dependent Manner

Autophagy is fundamental to myocardial ischemia/reperfusion (I/R) injury. Antithrombin III (AT) has been shown to protect cardiomyocytes against I/R injury; however, it is unknown whether it modulates autophagy. The objective of this study was to investigate whether AT regulates autophagy during I/R...

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Bibliographic Details
Main Authors: Kai-yu Huang, Jiao-ni Wang, Ying-ying Zhou, Shao-ze Wu, Lu-yuan Tao, Yang-pei Peng, Jia-qun Que, Yang-jing Xue, Kang-ting Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
antithrombin III
myocardial
ischemia reperfusion
autophagy
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00516/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00516/full

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