Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Abstract Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the formation of new blood vessels. In this s...

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Bibliographic Details
Main Authors: Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Biological Engineering
Subjects:
PHBV
Nucleus pulposus
HIF-2α
PT2399
Anoxic environment
Online Access:https://doi.org/10.1186/s13036-024-00407-6

Internet

https://doi.org/10.1186/s13036-024-00407-6

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