A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization

A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization

Benefits for vitamin E intake in diseases with inflammatory components have been described and related in part, to endogenously formed metabolites (long-chain metabolites, LCM). Here, we have evaluated the role of LCM in relieving asthma features. To this aim, the endogenous vitamin E metabolite α-1...

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Bibliographic Details
Main Authors: Ida Cerqua, Konstantin Neukirch, Michela Terlizzi, Elisabetta Granato, Elisabetta Caiazzo, Carla Cicala, Armando Ialenti, Raffaele Capasso, Oliver Werz, Rosalinda Sorrentino, Denis Seraphin, Jean-Jacques Helesbeux, Giuseppe Cirino, Andreas Koeberle, Fiorentina Roviezzo, Antonietta Rossi
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Pharmacological Research
Subjects:
α-13′-carboxychromanol
α-amplexichromanol
Vitamin E
Bronchial hyperreactivity
Cyclooxygenase
Lipoxygenase
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822001955

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http://www.sciencedirect.com/science/article/pii/S1043661822001955

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