Deciphering the Path of <i>S-nitrosation</i> of Human Thioredoxin: Evidence of an Internal NO Transfer and Implication for the Cellular Responses to NO

Deciphering the Path of <i>S-nitrosation</i> of Human Thioredoxin: Evidence of an Internal NO Transfer and Implication for the Cellular Responses to NO

Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved mainly through <i>S-nitrosation</i> where thioredoxin (hTrx) is pivotal in the S-transnitrosation to specific cellular targets. In this study, we use NMR spectroscopy and mass spectrometry...

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Bibliographic Details
Main Authors: Vitor S. Almeida, Lara L. Miller, João P. G. Delia, Augusto V. Magalhães, Icaro P. Caruso, Anwar Iqbal, Fabio C. L. Almeida
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
<i>S-nitrosation</i>
NMR
thioredoxin
post-translational modification
mechanism of action
Online Access:https://www.mdpi.com/2076-3921/11/7/1236

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https://www.mdpi.com/2076-3921/11/7/1236

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