Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line.
The inbred mouse is an invaluable model for human biology and disease. Nevertheless, when considering genetic mechanisms of variation and disease, it is important to appreciate the significant differences in the spectra of spontaneous mutations that distinguish these species. While insertions of tra...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-01-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1331978?pdf=render |
| _version_ | 1819231341637533696 |
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| author | Irina A Maksakova Mark T Romanish Liane Gagnier Catherine A Dunn Louie N van de Lagemaat Dixie L Mager |
| author_facet | Irina A Maksakova Mark T Romanish Liane Gagnier Catherine A Dunn Louie N van de Lagemaat Dixie L Mager |
| author_sort | Irina A Maksakova |
| collection | DOAJ |
| description | The inbred mouse is an invaluable model for human biology and disease. Nevertheless, when considering genetic mechanisms of variation and disease, it is important to appreciate the significant differences in the spectra of spontaneous mutations that distinguish these species. While insertions of transposable elements are responsible for only approximately 0.1% of de novo mutations in humans, the figure is 100-fold higher in the laboratory mouse. This striking difference is largely due to the ongoing activity of mouse endogenous retroviral elements. Here we briefly review mouse endogenous retroviruses (ERVs) and their influence on gene expression, analyze mechanisms of interaction between ERVs and the host cell, and summarize the variety of mutations caused by ERV insertions. The prevalence of mouse ERV activity indicates that the genome of the laboratory mouse is presently behind in the "arms race" against invasion. |
| first_indexed | 2024-12-23T11:43:26Z |
| format | Article |
| id | doaj.art-cdeef4de68c54c20ae0a333ad491349d |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-23T11:43:26Z |
| publishDate | 2006-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-cdeef4de68c54c20ae0a333ad491349d2022-12-21T17:48:24ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042006-01-0121e210.1371/journal.pgen.0020002Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line.Irina A MaksakovaMark T RomanishLiane GagnierCatherine A DunnLouie N van de LagemaatDixie L MagerThe inbred mouse is an invaluable model for human biology and disease. Nevertheless, when considering genetic mechanisms of variation and disease, it is important to appreciate the significant differences in the spectra of spontaneous mutations that distinguish these species. While insertions of transposable elements are responsible for only approximately 0.1% of de novo mutations in humans, the figure is 100-fold higher in the laboratory mouse. This striking difference is largely due to the ongoing activity of mouse endogenous retroviral elements. Here we briefly review mouse endogenous retroviruses (ERVs) and their influence on gene expression, analyze mechanisms of interaction between ERVs and the host cell, and summarize the variety of mutations caused by ERV insertions. The prevalence of mouse ERV activity indicates that the genome of the laboratory mouse is presently behind in the "arms race" against invasion.http://europepmc.org/articles/PMC1331978?pdf=render |
| spellingShingle | Irina A Maksakova Mark T Romanish Liane Gagnier Catherine A Dunn Louie N van de Lagemaat Dixie L Mager Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. PLoS Genetics |
| title | Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. |
| title_full | Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. |
| title_fullStr | Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. |
| title_full_unstemmed | Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. |
| title_short | Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. |
| title_sort | retroviral elements and their hosts insertional mutagenesis in the mouse germ line |
| url | http://europepmc.org/articles/PMC1331978?pdf=render |
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