Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis

Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease with few therapeutic options. However, the immune system, including natural killer (NK) cells, is linked to ALS progression and may constitute a viable therapeutic ALS target. Tofacitinib is an FDA-approved immuno...

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Bibliographic Details
Main Authors: Claudia Figueroa-Romero, Alina Monteagudo, Benjamin J. Murdock, Joshua P. Famie, Ian F. Webber-Davis, Caroline E. Piecuch, Samuel J. Teener, Crystal Pacut, Stephen A. Goutman, Eva L. Feldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
ALS
NK cells
immune system
tofacitinib
JAK/STAT
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.773288/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.773288/full

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