Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery

Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery

In this study, we demonstrate how encapsulating a conserved influenza ectodomain matrix-2 protein virus-like particle (M2e5x VLP) into a pre-crosslinked bovine serum albumin (BSA) polymeric matrix enhances in vitro antigen immunogenicity and in vivo efficacy. The spray-dried M2e5x VLP-loaded BSA mic...

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Bibliographic Details
Main Authors: Keegan Braz Gomes, Ipshita Menon, Priyal Bagwe, Lotika Bajaj, Sang-Moo Kang, Martin J. D’Souza
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Viruses
Subjects:
vaccine
virus-like particle
influenza
microparticle
live-cell imaging
Online Access:https://www.mdpi.com/1999-4915/14/9/1920

Internet

https://www.mdpi.com/1999-4915/14/9/1920

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