Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.

In mammals DNA methylation occurs at position 5 of cytosine in a CpG context and regulates gene expression. It plays an important role in diseases and inhibitors of DNA methyltransferases (DNMTs)--the enzymes responsible for DNA methylation--are used in clinics for cancer therapy. The most potent in...

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Bibliographic Details
Main Authors: Christine Champion, Dominique Guianvarc'h, Catherine Sénamaud-Beaufort, Renata Z Jurkowska, Albert Jeltsch, Loïc Ponger, Paola B Arimondo, Anne-Laure Guieysse-Peugeot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2927531?pdf=render

Internet

http://europepmc.org/articles/PMC2927531?pdf=render

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