Targeting SNARE-Mediated Vesicle Transport to Block Invadopodium-Based Cancer Cell Invasion

Targeting SNARE-Mediated Vesicle Transport to Block Invadopodium-Based Cancer Cell Invasion

During metastasis, cancer cells can invade extracellular matrix (ECM) through a process mediated by matrix-degrading protrusions of the plasma membrane, termed invadopodia. Formation of invadopodia correlates with cells’ invasive and metastatic potential, and thus presents a potential target for the...

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Bibliographic Details
Main Authors: Genya Gorshtein, Olivia Grafinger, Marc G. Coppolino
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
invadopodia formation
vesicle traffic
SNARE
membrane type 1–matrix metalloproteinase
invasion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.679955/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.679955/full

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