HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis

HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis

Abstract SAMHD1, a human host factor found in myeloid cells which restricts HIV-1 replication. It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells. The viral accessory protein, Vpx, exists only in SIVmac/HIV-2 particles. Vpx in SIVmac can induce pr...

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Bibliographic Details
Main Authors: Ahlam Mohamed, Talal Bakir, Huda Al-Hawel, Ibtihaj Al-Sharif, Razan Bakheet, Lubna Kouser, Valarmathy Murugaiah, Maha Al-Mozaini
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00415-2

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https://doi.org/10.1038/s41598-021-00415-2

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