Formulation of Polymers-Based Methotrexate Patches and Investigation of the Effect of Various Penetration Enhancers: In Vitro, Ex Vivo and In Vivo Characterization

Formulation of Polymers-Based Methotrexate Patches and Investigation of the Effect of Various Penetration Enhancers: In Vitro, Ex Vivo and In Vivo Characterization

The present study aimed to prepare methotrexate-loaded transdermal patches with different blends of hydrophobic and hydrophilic polymers (Eudragit S-100 and hydroxypropyl methylcellulose) at different concentrations. The polymers employed in transdermal patches formulations served as controlled agen...

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Bibliographic Details
Main Authors: Muhammad Shahid Latif, Asif Nawaz, Sheikh Abdur Rashid, Muhammad Akhlaq, Asif Iqbal, Muhammad Jamil Khan, Muhammad Shuaib Khan, Vuanghao Lim, Mulham Alfatama
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Polymers
Subjects:
hydroxypropyl methylcellulose (HPMC)
Eudragit S-100 (ES-100)
psoriasis
transdermal patches
methotrexate (MTX)
Online Access:https://www.mdpi.com/2073-4360/14/11/2211

Internet

https://www.mdpi.com/2073-4360/14/11/2211

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