The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity

The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity

Abstract Background The ketogenic diet (KD)has been considered an effective treatment for epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported that the KD feeding increased Neuregulin 1 (NRG1) expression in the hippocampus; disruption of NRG1 signaling by genetical...

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Bibliographic Details
Main Authors: Jin Wang, Jie Huang, Shan Yao, Jia-Hui Wu, Hui-Bin Li, Feng Gao, Ying Wang, Guo-Bin Huang, Qiang-Long You, Jianhua Li, Xiaohui Chen, Xiang-Dong Sun
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cell & Bioscience
Subjects:
Neuregulin 1
Ketogenic diet
Acetylation
ErbB4 kinase activity
Epilepsy
Online Access:https://doi.org/10.1186/s13578-021-00611-7

Internet

https://doi.org/10.1186/s13578-021-00611-7

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