Extracellular vesicles from cancer cell lines of different origins drive the phenotype of normal oral fibroblasts in a CAF-like direction

Extracellular vesicles from cancer cell lines of different origins drive the phenotype of normal oral fibroblasts in a CAF-like direction

IntroductionNormal oral fibroblasts (NOFs) are located in the connective tissue of the oral mucosa. The NOFs play an important role in wound healing, tumor progression, and metastasis. They are subjected to influence by external and internal stimuli, among them extracellular vesicles (EVs), that are...

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Bibliographic Details
Main Authors: Tine M. Søland, Aleksandra Lipka, Ann-Kristin Ruus, Ann-Kristin Molværsmyr, Hilde K. Galtung, Trude M. Haug
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Oncology
Subjects:
oral cancer
oral squamous cell carcinoma
cancer-associated fibroblasts
phenotype
proliferation
migration
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1456346/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1456346/full

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