Single-Cell Analysis Uncovers Osteoblast Factor Growth Differentiation Factor 10 as Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation Associated with Plaque Rupture in Human Carotid Artery Disease

Single-Cell Analysis Uncovers Osteoblast Factor Growth Differentiation Factor 10 as Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation Associated with Plaque Rupture in Human Carotid Artery Disease

(1) Background: Vascular smooth muscle cells (VSMCs) undergo a complex phenotypic switch in response to atherosclerosis environmental triggers, contributing to atherosclerosis disease progression. However, the complex heterogeneity of VSMCs and how VSMC dedifferentiation affects human carotid artery...

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Bibliographic Details
Main Authors: Karim J. Brandt, Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Kapka Miteva
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
vascular smooth muscle cells
atherosclerosis
carotid artery disease
Online Access:https://www.mdpi.com/1422-0067/23/3/1796

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https://www.mdpi.com/1422-0067/23/3/1796

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