Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single‐Domain Llama‐Derived Antibody

Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single‐Domain Llama‐Derived Antibody

Background In the presence of arterial stenosis, collateral artery growth (arteriogenesis) can alleviate ischemia and preserve tissue function. In patients with poorly developed collateral arteries, Gal‐2 (galectin 2) expression is increased. In vivo administration of Gal‐2 inhibits arteriogenesis....

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Bibliographic Details
Main Authors: Maurits R. Hollander, Matthijs F. Jansen, Luuk H. G. A. Hopman, Edward Dolk, Peter M. van de Ven, Paul Knaapen, Anton J. Horrevoets, Esther Lutgens, Niels van Royen
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
antibody
collateral circulation
macrophage
murine model
perfusion defect
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012806

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.012806

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