Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease

A controlled and self-limiting inflammatory reaction generally results in removal of the injurious agent and repair of the damaged tissue. However, in chronic inflammation, immune responses become dysregulated and prolonged, leading to tissue destruction. The role of metabolic reprogramming in orche...

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Bibliographic Details
Main Authors: Cristina Dumitru, Agnieszka M. Kabat, Kevin J. Maloy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00540/full