Conformational and thermal stability improvements for the large-scale production of yeast-derived rabbit hemorrhagic disease virus-like particles as multipurpose vaccine.

Conformational and thermal stability improvements for the large-scale production of yeast-derived rabbit hemorrhagic disease virus-like particles as multipurpose vaccine.

Recombinant virus-like particles (VLP) antigenically similar to rabbit hemorrhagic disease virus (RHDV) were recently expressed at high levels inside Pichia pastoris cells. Based on the potential of RHDV VLP as platform for diverse vaccination purposes we undertook the design, development and scale-...

Full description

Bibliographic Details
Main Authors: Erlinda Fernández, Jorge R Toledo, Lídice Méndez, Nemecio González, Francisco Parra, José M Martín-Alonso, Miladys Limonta, Kosara Sánchez, Ania Cabrales, Mario P Estrada, Alina Rodríguez-Mallón, Omar Farnós
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3584067?pdf=render

Internet

http://europepmc.org/articles/PMC3584067?pdf=render

Similar Items