DNA-methylation and genomic copy number in primary tumors and corresponding lymph node metastases in prostate cancer from patients with low and high Gleason score

DNA-methylation and genomic copy number in primary tumors and corresponding lymph node metastases in prostate cancer from patients with low and high Gleason score

Purpose: In prostate cancer, the indication to irradiate the pelvic lymphatic pathways in clinical node-negative patients is solely based on clinical nomograms. To define biological risk patterns of lymphatic spread, we studied DNA-methylation and genomic copy number in primary tumors and correspond...

Full description

Bibliographic Details
Main Authors: Kristian Unger, Julia Hess, Vera Link, Alexander Buchner, Chukwuka Eze, Minglun Li, Christian Stief, Thomas Kirchner, Frederick Klauschen, Horst Zitzelsberger, Maximilian Niyazi, Ute Ganswindt, Nina-Sophie Schmidt-Hegemann, Claus Belka
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Prostate lymphatic spread
DNA-methylation
Signature
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630823000113

Internet

http://www.sciencedirect.com/science/article/pii/S2405630823000113

Similar Items