Increased Expression and Amplification of blaKPC-2 Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain

Increased Expression and Amplification of blaKPC-2 Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain

ABSTRACT Ceftazidime/avibactam (CAZ/AVI) is regarded as an effective alternative antibiotic for the clinical treatment of Klebsiella pneumoniae carbapenemase (KPC)-producing isolates. As resistance has been reported in some strains, it is critical to understand the key mechanisms contributing to the...

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Bibliographic Details
Main Authors: Xinhui Li, Jisheng Zhang, Chengru Yang, Jie Li, Jianmin Wang, Wan Huang, Lingyi Zeng, Xushan Liang, Wenzhang Long, Xiaoli Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
ceftazidime-avibactam resistance
carbapenem-resistant Klebsiella pneumoniae
blaKPC-2
IS26
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00955-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00955-22

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