An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection

An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection

Porcine reproductive and respiratory syndrome virus (PRRSV) remains a leading cause of economic loss in pig farming worldwide. Existing commercial vaccines, all based on modified live or inactivated PRRSV, fail to provide effective immunity against the highly diverse circulating strains of both PRRS...

Full description

Bibliographic Details
Main Authors: Rory C. F. de Brito, Kerry Holtham, Jessica Roser, Jack E. Saunders, Yvonne Wezel, Summer Henderson, Thekla Mauch, Beatriz Sanz-Bernardo, Jean-Pierre Frossard, Matthieu Bernard, Fabian Z. X. Lean, Alejandro Nunez, Simon Gubbins, Nicolás M. Suárez, Andrew J. Davison, Michael J. Francis, Michael Huether, Hafid Benchaoui, Jeremy Salt, Veronica L. Fowler, Michael A. Jarvis, Simon P. Graham
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
porcine reproductive and respiratory syndrome virus
T cell
vaccine
bovine herpesvirus 4
immunogenicity
protective efficacy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201973/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201973/full

Similar Items