Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study

Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study

Abstract Cystic fibrosis (CF) is an autosomal recessive disorder characterized by respiratory failure due to a vicious cycle of defective Cystic Fibrosis Transmembrane conductance Regulator (CFTR) function, chronic inflammation and recurrent bacterial and fungal infections. Although the recent intro...

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Bibliographic Details
Main Authors: Barbara Cellini, Gioena Pampalone, Emidio Camaioni, Marilena Pariano, Flavia Catalano, Teresa Zelante, Mirco Dindo, Lara Macchioni, Alessandra Di Veroli, Roberta Galarini, Fabiola Paoletti, Magdalena Davidescu, Claudia Stincardini, Gianluca Vascelli, Marina Maria Bellet, Julie Saba, Stefano Giovagnoli, Giorgio Giardina, Luigina Romani, Claudio Costantini
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-50121-4

Internet

https://doi.org/10.1038/s41598-023-50121-4

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