Efficient Two-Stage Analysis for Complex Trait Association with Arbitrary Depth Sequencing Data

Efficient Two-Stage Analysis for Complex Trait Association with Arbitrary Depth Sequencing Data

Sequencing-based genetic association analysis is typically performed by first generating genotype calls from sequence data and then performing association tests on the called genotypes. Standard approaches require accurate genotype calling (GC), which can be achieved either with high sequencing dept...

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Bibliographic Details
Main Authors: Zheng Xu, Song Yan, Shuai Yuan, Cong Wu, Sixia Chen, Zifang Guo, Yun Li
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Stats
Subjects:
association study
next-generation sequencing
genotype
genotype likelihood function
testing
Online Access:https://www.mdpi.com/2571-905X/6/1/29

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