Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluoro substituted β-lactams as analogues of the tubul...

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Bibliographic Details
Main Authors: Azizah M. Malebari, Gabriela Duffy Morales, Brendan Twamley, Darren Fayne, Mohemmed Faraz Khan, Eavan C. McLoughlin, Niamh M. O’Boyle, Daniela M. Zisterer, Mary J. Meegan
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
combretastatin A-4
antiproliferative activity
fluorinated β-lactams
Reformatsky reaction
inhibition of tubulin polymerisation
breast cancer
Online Access:https://www.mdpi.com/1424-8247/15/9/1044

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https://www.mdpi.com/1424-8247/15/9/1044

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