Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2

Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2

Abstract Soft-tissue sarcomas (STS) emerges as formidable challenges in clinics due to the complex genetic heterogeneity, high rates of local recurrence and metastasis. Exploring specific targets and biomarkers would benefit the prognosis and treatment of STS. Here, we identified RCC1, a guanine-nuc...

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Bibliographic Details
Main Authors: Mingzhi Zhuang, Fengyue Li, Hong Liang, Yongfu Su, Lei Cheng, Bingkai Lin, Jun Zhou, Runzhi Deng, Linying Chen, Peng Lyu, Zhonglei Lu
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06629-2

Internet

https://doi.org/10.1038/s41419-024-06629-2

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