Potentiation of Collagen Deposition by the Combination of Substance P with Transforming Growth Factor Beta in Rat Skin Fibroblasts

Potentiation of Collagen Deposition by the Combination of Substance P with Transforming Growth Factor Beta in Rat Skin Fibroblasts

A role for substance P has been proposed in musculoskeletal fibrosis, with effects mediated through transforming growth factor beta (TGFβ). We examined the in vitro effects of substance P on proliferation, collagen secretion, and collagen deposition in rat primary dermal fibroblasts cultured in medi...

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Bibliographic Details
Main Authors: Brendan A. Hilliard, Mamta Amin, Steven N. Popoff, Mary F. Barbe
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
substance p
TGFbeta
fibroblasts
collagen
proliferation
smooth muscle actin
Online Access:https://www.mdpi.com/1422-0067/25/3/1862

Internet

https://www.mdpi.com/1422-0067/25/3/1862

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