Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer

Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is especially hypoxic and composed of heterogeneous cell populations containing hypoxia-adapted cells. Hypoxia as a microenvironment of PDAC is known to cause epithelial-mesenchymal transition (EMT) and resistance to therapy. Therefore, cells adapted to hypoxi...

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Bibliographic Details
Main Authors: Koichiro Kumano, Hiromitsu Nakahashi, Pakavarin Louphrasitthiphol, Yukihito Kuroda, Yoshihiro Miyazaki, Osamu Shimomura, Shinji Hashimoto, Yoshimasa Akashi, Bryan J. Mathis, Jaejeong Kim, Yohei Owada, Colin R. Goding, Tatsuya Oda
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
3D organoid
pancreatic cancer
hypoxia
tumor heterogeneity
selection bias
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1327772/full

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https://www.frontiersin.org/articles/10.3389/fcell.2024.1327772/full

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