Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy

Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy

Mutations or triplication of the alpha synuclein (ASYN) gene contribute to synucleinopathies including Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent evidence suggests that ASYN also plays an important role in amyloid-induced neurotoxicity, a...

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Bibliographic Details
Main Authors: Suzhen Lin, André D.G. Leitão, Savannah Fang, Yingli Gu, Sophia Barber, Rhiannon Gilliard-Telefoni, Alfredo Castro, Kijung Sung, Ruinan Shen, Jazmin B. Florio, Michael L. Mante, Jianqing Ding, Brian Spencer, Eliezer Masliah, Robert A. Rissman, Chengbiao Wu
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Parkinson's disease
Alpha synuclein
APP
Rab5
Rab7
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000244

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http://www.sciencedirect.com/science/article/pii/S0969996123000244

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