Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody

Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody

IntroductionObesity has been linked to vascular dysfunction, cognitive impairment and neurodegenerative diseases. However, experimental models that recapitulate brain pathology in relation to obesity and vascular dysfunction are still lacking.MethodsIn this study we performed the histological and hi...

Full description

Bibliographic Details
Main Authors: Florine Seidel, Kees Fluiter, Robert Kleemann, Nicole Worms, Anita van Nieuwkoop, Martien P. M. Caspers, Nikolaos Grigoriadis, Amanda J. Kiliaan, Frank Baas, Iliana Michailidou, Martine C. Morrison
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
obesity
aging
brain
neurodegeneration
astrogliosis
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1205261/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1205261/full

Similar Items