Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS

Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS

Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcriptional dysregulation may contribute to motor neuron death. In this stu...

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Bibliographic Details
Main Authors: Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L. Ryu, Neil W. Kowall, Hoon Ryu, Junghee Lee
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Biomedical Science
Subjects:
Amyotrophic lateral sclerosis
LSD1
Spermidine
Histone H3K4 dimethylation
Motor neuron
Online Access:https://doi.org/10.1186/s12929-022-00890-3

Internet

https://doi.org/10.1186/s12929-022-00890-3

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