Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis pathogenesis has been unclear, but here we demonstrate that NETs drive inflammatory responses in skin through acti...

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Bibliographic Details
Main Authors: Shuai Shao, Hui Fang, Erle Dang, Ke Xue, Jieyu Zhang, Bing Li, Hongjiang Qiao, Tianyu Cao, Yuchen Zhuang, Shengxian Shen, Tongmei Zhang, Pei Qiao, Caixia Li, Johann E. Gudjonsson, Gang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
psoriasis
neutrophil extracellular traps
IL-36
TLR4
keratinocyte
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00746/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00746/full

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