Tau-dependent HDAC1 nuclear reduction is associated with altered VGluT1 expression

Tau-dependent HDAC1 nuclear reduction is associated with altered VGluT1 expression

During AD pathology, Tau protein levels progressively increase from early pathological stages. Tau altered expression causes an unbalance of Tau subcellular localization in the cytosol and in the nuclear compartment leading to synaptic dysfunction, neuronal cell death and neurodegeneration as a cons...

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Bibliographic Details
Main Authors: Giacomo Siano, Giuseppe Madaro, Maria Claudia Caiazza, Awatef Allouch, Martina Varisco, Marianna Mignanelli, Antonino Cattaneo, Cristina Di Primio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Tau
HDAC1 histone deacetylase
VGluT1
tauopathies
nuclear HDAC1 reduction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1151223/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1151223/full

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