TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-β

TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-β

TRAIL, a member of TNF superfamily, is a potent inducer of neuronal death. Neurotoxic effects of TRAIL appear mediated by its death receptor TRAIL-R2/DR5. To assess the role of TRAIL/TRAIL-R2 pathway in AD-related neurodegeneration, we studied the impact of the treatment with amyloid-β (Aβ) upon cel...

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Bibliographic Details
Main Authors: Giulia Di Benedetto, Chiara Burgaletto, Maria Francesca Serapide, Rosario Caltabiano, Antonio Munafò, Carlo Maria Bellanca, Rosaria Di Mauro, Renato Bernardini, Giuseppina Cantarella
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
TRAIL-R2
Alzheimer’s disease
apoptosis
neuroinflammation
Online Access:https://www.mdpi.com/1422-0067/23/19/11625

Internet

https://www.mdpi.com/1422-0067/23/19/11625

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